LncRNA HOXB-AS3 encodes a conserved 53-aa peptide named HOXB-AS3, which competitively recognizes the arginine residues in the RGG motif of hnRNPA1 and antagonizes hnRNPA1-dependent PKM splicing, leading to the inhibition of PKM2 isoform and glucose metabolism in CRC cells 68. The gene discussed is PKM; the disease is colorectal carcinoma.