SRSF1 and glioblastoma: Furthermore, it has been convincingly found that circSMARCA5 hijacks SRSF1 and impedes the binding of SRSF1 protein to vascular endothelial growth factor A (VEGFA) pre-mRNA, thus reducing the ratio of pro-angiogenic (Iso8a) to anti-angiogenic (Iso8b) isoforms and inhibiting angiogenesis in glioblastoma multiforme (GBM) cells 58.