Additionally, CircSMARCA5, derived from the back-splicing of exon 15 and exon 16 of SMARCA5, binds to the genomic location of SMARCA5 to form an R-loop, which pauses transcription at exon 15 of SMARCA5 and produces truncated nonfunctional proteins, thus increasing sensitivity to cisplatin chemotherapy of breast cancer 46. This evidence concerns the gene SMARCA5 and breast carcinoma.