As shown in Figure 3, LOC90024 encodes a splicing regulatory small protein (SRSP) that enhances the binding of SRSF3 to the exon 3 of Sp4 pre-mRNA, which induces the generation of long Sp4 isoform (encoding L-Sp4 protein), whereas suppresses short Sp4 isoform (encoding S-Sp4 peptide), ultimately promoting CRC tumorigenesis and progression 67. The gene discussed is SP4; the disease is colorectal carcinoma.