Additionally, CircSMARCA5, derived from the back-splicing of exon 15 and exon 16 of SMARCA5, binds to the genomic location of SMARCA5 to form an R-loop, which pauses transcription at exon 15 of SMARCA5 and produces truncated nonfunctional proteins, thus increasing sensitivity to cisplatin chemotherapy of breast cancer 46. Here, SMARCA5 is linked to breast cancer.