PTEN and non-small cell lung carcinoma: In PTC, NEAT1_2 significantly promotes cell growth and metastasis by acting as a sponge of miR-106b-5p to derepress ATAD2 expression 39; while in NSCLC, RBM10 regulates AS of NEAT1 to downregulate NEAT1_2 expression, ultimately affecting the invasion and metastasis of NSCLC by suppressing the activation of the PTEN/PI3K/AKT/mTOR signaling pathway 38.