Caveolin-1 overexpression has also been documented in 5-fluorouracil-resistant colon cancer cells 80, cisplatin-resistant ovarian cancer cells 81, PTX-resistant breast and lung cancer cells 82, as well as in trastuzumab emtansine-resistant gastric cancer cells and human epidermal growth factor receptor 2-positive breast cancer cells 83. The gene discussed is CAV1; the disease is malignant colon neoplasm.