For example, after excluding any ADRD cases that occurred during the first 5 years, those who received angiotensin-II inhibiting antihypertensives were significantly more likely to develop AD (1.26, 1.04–1.52), vascular dementia (1.35, 1.01–1.81), and total ADRD (1.22, 1.02–1.45) than patients who received angiotensin-II stimulating antihypertensive drugs. This evidence concerns the gene AGT and Alzheimer disease.