AGT and Alzheimer disease: However, because of the scope and focus of this manuscript on the risk of AD and other types of ADRD between patients receiving angiotensin II–stimulating antihypertensive medications and those receiving angiotensin II–inhibiting antihypertensive medications, we were unable to address antihypertensive drugs acting in the central or peripheral nervous system and their effects on the risk of ADRD (47), which need to be explored further in future studies.