NECTIN4 and Cowden disease: Recombinant receptor-Fc proteins generated by fusing SLAM or/and Nectin-4 extracellular domain to the N terminal of canine IgG-B Fc region may be a promising choice for early CD treatment, because the presence of the Fc domain may confer greater stability to some proteins, and enhance the expression of proteins in mammalian cells that are otherwise difficult to produce (37).