Additionally, no significance of PD-L1 level were observed among studied ICC subgroups according to BTS status, varying from results from Shi et al. who reported lower PD-L1 expression in tumorous tissue of ICC patients with HL compared with HBV-positive ICC patients 42, the possible reasons might lie in the distinct grouping method and small sample sizes investigated in both two studies. The gene discussed is CD274; the disease is Hodgkins lymphoma.