The elevated levels of the cytoplasmicFOXP3 (cFOXP3)/nuclear FOXP3 (nFOXP3) ratio within tumor infiltrating CD4(+) T cells was proposed as a predictor of OSCC recurrence 51, and alternative splicing of FOXP3 (FOXP3Δ2, FOXP3Δ7, and FOXP3Δ2Δ7 isoforms) may play a critical mechanism which enables different aspects of FOXP3 function in T cells 52. The gene discussed is CD4; the disease is neoplasm.