For the correlations and hazard of these risk factors of OSCC to FOXP3 expression, a previous study of pediatric asthma has suggested that environmental tobacco smoke (ETS) exposure and passive smoking could induce pediatric asthma by affecting the balance of Treg/Th17 cells, and passive smoking was associated with significantly reduced levels of FOXP3 and tumor growth factor-β, which were associated with Treg cells 36. This evidence concerns the gene FOXP3 and asthma.