Previous studies have suggested that the tumor-infiltrating FOXP3 positive T cells were associated with development and poor prognosis in OSCC 13, 17, and the FOXP3 polymorphisms were associated with cancer development and prognosis in various cancers such as cervical cancer 18, 19, gastric adenocarcinoma 20, and colorectal cancer 21. Here, FOXP3 is linked to colorectal cancer.