On the other hand, we demonstrated, for the first time, that ultrasound not only does not affect healthy CD3/CD8 lymphocyte viability, but their functions and activation are fully preserved, suggesting the absence of any genotoxic effect after US-treatment; furthermore, we demonstrated that in our experimental condition, different leukemic cells, which differ in their lineage and genotypes (AML or ALL cells), could be affected differently by US treatment. This evidence concerns the gene CD8A and acute lymphoblastic leukemia.