Omentum mesothelial cells (MCs) incubated with SKOV3 cell conditioned medium acquired a spindle morphology with increased expression of MMT markers such as α-SMA, fibronectin, collagen I, vascular endothelial growth factor (VEGF) and TGF-β I 36, indicating accumulation of large numbers of CAFs from PMCs via MMT processes is essential for tumor peritoneal metastasis 36-38. This evidence concerns the gene VEGFA and neoplasm.