For example, EOC derived exosome miR-222-3p has been shown to promote TAMs polarization to inhibit anti-tumor immunity via activation of the signal transducer and activator of transcription 3 (STAT3) pathway64 , while elevated miR-200b levels in the plasma of ovarian cancer patients have been reported to promote macrophage M2 polarization but inhibit M1 polarization65, with higher expression levels enhancing proliferation and invasion of tumor cells. This evidence concerns the gene STAT3 and ovarian cancer.