The heat map of DEGs related with cell differentiation of BaF3-T315I and K562 cells can be seen from Figure 6C. Furthermore, the most optimal pathway related to cell differentiation promoted by JOA was the chronic myeloid leukemia signaling pathway (genes e.g. c-MYC, CDKN2A (cell-cycle inhibitors), CdKN1A, Cdk4, Cdk6, RUNX1, Bcl-2, Sos2, Araf, Kras, E2f2, Smad4 and Chuk were enriched) in BaF3-T315I cells. Here, SMAD4 is linked to myeloid leukemia.