The antihyperglycemic mechanism of herbal medicinal plants in diabetes-induced animal models could be due to their ability to restore pancreatic function by increasing insulin production and insulin sensitivity in peripheral tissues [3, 134] to enhance glucose uptake [135], as well as the inhibition of glucose transporter proteins in cell membranes by flavonoid glycosides [24, 133, 136]. Here, INS is linked to diabetes mellitus.