In high glucose microenvironments, GSK-3b activation as well as Wnt pathway suppression impede BMSC migration and proliferation, however, lithium chloride, an inhibitor of GSK-3b, may restore the functionality of BMSCs (46), according to Zhang et al. Moreover, Yu’s study demonstrated the activation of GSK3b in diabetic osteoporosis and its deleterious osteogenic affected BMSCs in a high glucose milieu through the β-catenin/Tcf7/Ccn4 signaling axis inhibition, and thus provide unprecedented perspectives into diabetes osteopathy (48). Here, GSK3B is linked to diabetes mellitus.