According to the International Diabetes Federation, the alarming number of diabetics worldwide has surpassed 537 million as of 2021, and the most striking features of diabetes include chronically higher-than-standard fasting and random blood glucose, which either induce insulin deficiency [Type 1 diabetes mellitus (T1DM)] due to damage to pancreatic beta cells or progressive insulin secretion defect [Type 2 diabetes mellitus (T2DM)] from insulin resistance (24). The gene discussed is INS; the disease is type 2 diabetes mellitus.