Regarding metabolic markers, the group with obesity showed significantly elevated blood pressure (BP; systolic (p < 0.001) and diastolic (p < 0.02)); higher glucose (p < 0.02), insulin (p < 0.001), HOMA-IR (p < 0.001), TG (p < 0.001), and TG/HDL-C ratio (p < 0.02); and lower levels of HDL-C (p < 0.02) (Table 1) compared with the control. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.