TBX21 and obesity due to melanocortin 4 receptor deficiency: The higher transcription of mRNA FOXP3 and IL-10 (Treg markers), accompanied by a high transcription of TBX21 and IFNG (Th1 markers), GATA3 and IL-4 (Th2 markers) (Figure 5) indicated the inflammatory status in the group with obesity and an altered Treg function.