When adjusted for age, sex, race, educational level, marital status, monthly household income, city grade, hypertension, dyslipidemia, alcohol use and smoking status, higher HbA1c levels were still significantly associated with an increased risk of elevated hs-CRP [adjusted OR 2.31 (1.47, 3.65), Padjusted ≤ 0.001]. The gene discussed is CRP; the disease is hypertensive disorder.