Here we report the use of an ABE-mediated gene editing strategy for single-swap editing as a correction strategy for the three most therapeutically relevant exons—DMD exons 45, 51, and 53—in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPSC-CMs), which could be beneficial for nearly 30% of all DMD patients.19 Here, DMD is linked to Duchenne muscular dystrophy.