Here, we report patients from various IEI categories (7), including combined immunodeficiency (CID) affecting humoral and cellular immunity: CD40 ligand deficiency (CD40L), CID associated with syndromic features: Wiskott-Aldrich syndrome (WAS) with congenital thrombocytopenia and DiGeorge syndrome (thymic defect with additional congenital anomalies). The gene discussed is CD40LG; the disease is Wiskott-Aldrich syndrome.