Upregulated terms such as “iron ion transport”, “transferrin transport”, “regulation of sterol transport”, “cholesterol efflux” and “triglyceride metabolic process” and downregulated terms such as “lipase inhibitor activity”, “plasma lipoprotein clearance”, and “negative regulation of endocytosis” were observed in M2 alveolar macrophages in COPD lungs (Figure 4B). The gene discussed is TF; the disease is chronic obstructive pulmonary disease.