Increases in intracellular ferritin (Fth1, Ftl) and Cybb, as well as decreases in Acsl1, Slc3a2 and Gpx4, were observed in AM-CLST13 cells (R8) sorted by FACS from mild-moderate COPD patients compared to smokers without COPD, indicating that M2 alveolar macrophages had marked changes in ferroptosis (Figure 5B). The gene discussed is GPX4; the disease is chronic obstructive pulmonary disease.