CD4 and rheumatoid arthritis: The majority were CD4+ and, of these, three populations were present in both unstimulated and stimulated states, including enrichment of Th1 and Th17 subsets (CD4+ T-bet+ IL-17+ and CD4+ T-bet+ IL-2+ cell clusters) and depletion of a Treg-like subset (CD4+ FoxP3+ IL-2+) in RA (Table 3, Figure 6).