Specifically, LPS induction of genes involved in IL-17 signaling (Ccl2, Cxcl10, ll1b, IL6 and Csf2), Th17 cell differentiation (Il1b, Il27, Il6 and Il23a), and IBD (IL1a, Il1b, Il12b, IL6 and Il18) was restrained in a dose-dependent manner (Figure 1H, Supplementary Figure S1F). This evidence concerns the gene IL1B and inflammatory bowel disease.