Benzodiazepines, a drug that can enhance GABA(A)R-mediated anion transport, could depolarize melanoma cells and reduce tumor growth, as well as potentiate radiation and immune checkpoint inhibitor response by promoting direct anti-tumor activity and infiltration of CD8(+) T cell (134).Baclofen, a GABA(B) receptor agonist, inhibits human HCC growth through the downregulation of intracellular cAMP level and upregulation of p21(WAF1) (135).GABA(B) receptor 1 signaling impaired the migration and invasion of colorectal cancer (CRC) cells by inhibiting EMT and the hippo/YAP1 pathway (136). The gene discussed is CD8A; the disease is melanoma.