Increased LC3-II at 3h and 6 h after CLP and sequentially decreased to the basal level at 9h and 18 h after CLP. In vitro study, siRNA knockdown of Atg7 on NRK-52E cells significantly declined the level of LC3-II. Declination of autophagy contributed to proximal tubular dysfunction at the late stage of sepsis. Here, ATG7 is linked to Sepsis.