It would be interesting for future research to examine the effects of epigenetic changes in macrophages on AGE expression and functionality and on the molecular pathways downstream of HDAC3 that are involved in macrophage polarization, metabolism, and function in the context of diabetes-associated atherosclerosis, such as NK-kB signaling (30), peroxisome proliferator-activated receptor gamma (PPARγ) signaling (31), STAT signaling (32), or mTor signaling (33). The gene discussed is PPARG; the disease is atherosclerosis.