(128) confirmed that DATS alleviated renal damage in DKD rats, and the expressions of ROS, NLRP3, ASC, Caspase-1, IL-1β and IL-18 were decreased, which suggested that DATS may be effective in treating DKD by inhibiting ROS/NLRP3/Caspase-1 pathway. This evidence concerns the gene IL18 and diabetic kidney disease.