Accumulative evidence demonstrates that many natural products could suppress systemic and renal inflammation by targeting nuclear transcription factor-κB (NF-κB), NLR family pyrin domain containing 3 (NLRP3) inflammasome, transforming growth factor-β (TGF-β) signaling pathway, and exhibit reno-protective effects on DKD (6). This evidence concerns the gene NFKB1 and diabetic kidney disease.