Survival curves were used to explore the prognostic implications of TANK expression in glioma in the six cohorts, and the results consistently revealed that TANK is an indicator of poor prognosis in glioma (TCGA, HR=2.85 (2.16-3.75); CGGA-693, HR=1.57 (1.28-1.91); GSE16011, HR=1.78 (1.37-2.32); Rembrandt, HR=1.45 (1.16-1.8); CGGA-301, HR=1.54 (1.15-2.07); CGGA-325, HR=2.11 (1.60-2.78), log-rank test P < 0.05, Figures 2A–F). The gene discussed is TANK; the disease is central nervous system cancer.