IKBKG and Autoimmunity: Subsequent studies identified TANK as an adaptor protein that interacts with canonical IKKs (NEMO and IKKγ) (31) and IKK-related kinases (TBK1 and IKKε) (32) to modulate NF-κB and TLR-induced antiviral pathways and prevent autoimmunity (32, 33).