TTN and central nervous system cancer: IDH1 and ATRX were not frequently mutated in gliomas with high TANK expression (IDH1, 43% and ATRX, 26%) compared with those with low TANK expression (IDH1, 78% and ATRX, 35%), while PTEN, TTN and EGFR were more frequently mutated in gliomas with high TANK expression (PTEN, 17%, TTN, 16% and EGFR, 15%) than in those with low-level TANK (PTEN, 4%, TTN, 10% and EGFR, 5%).