Human cancers frequently display hyperactivation of the Hippo signaling pathway and its downstream transcriptional coactivators Yes-associated protein 1 (YAP1) and Transcriptional activator with PDZ-binding motif (TAZ), in response to a variety of stimuli, including mechanical cues (Dupont et al., 2011; Panciera et al., 2017; Martinez et al., 2019). This evidence concerns the gene YAP1 and cancer.