AKT1 and dengue disease: Recently, phosphoinositide-3-kinase (PI3K)/AKT signal pathway, autophagy pathway, Ca2+ and mitochondrial homeostasis, extracellular signal-regulated kinase (ERK) pathway, and the regulation of microRNA have gradually become the focus of research to investigate the pathogenesis of DF (Zhao et al., 2016; Deng et al., 2020; Zhao et al., 2022).