CXCL-8 (interleukin 8 or IL-8), which is constitutively secreted by melanoma cells (Singh et al., 1994), is expressed on melanoma and endothelial cells by two high-affinity receptors for CXCL-8, CXCR1 and CXCR2 (Li et al., 2002), and activation of CXCL-8 signaling opens up cell proliferation, apoptosis inhibition, cell cycle control and cytoskeletal dynamics involving various downstream pathways and transcription factors. The gene discussed is CXCR2; the disease is melanoma.