When miR-494 was used to regulate LETMD1 expression, the proliferation, differentiation, and migration rates of HeLa cell lines increased slowly over 5 days, while the proportion of cancer cells decreased by 5%, the proportion of macrophages increased by 2%, and the proportion of dendritic cells increased by 3% after the expression of LETMD1 (Wen et al., 2022). This evidence concerns the gene LETMD1 and cancer.