MYC and cancer: For example, lncRNA-IGFBP4, as an oncogene and a tumor suppressor in lung, prostate, breast, and other cancers, has been found to participate in autophagic response by interacting with c-Myc and to indirectly inhibit autophagy in HeLa cells of CC origin based on the observation of LC3 puncta formed in GFP-LC3 in engineered HeLa cell lines (Zhang et al., 2022a).