GPT and Acute hepatitis: Without IL-37 pretreatment, MCMV-infected mice at dpi 3 were presented with significantly elevated serum ALT and AST levels when compared with uninfected mice (MCMV vs. PBS groups, P < 0.01–0.05, Figure 1(a)), which, along with histopathological changes described below, confirms MCMV-induced acute hepatitis.