In conclusion, the present study suggested that exogenous IL-37 can inhibit the accumulation and maturation of cDCs in the liver and spleen of mice at the early stage of acute MCMV infection, and it also promoted the induction of Tregs in the spleen and suppressed the cytokine storm, all leading to the overall control of the excessive immune response and thus alleviated MCMV-infected hepatitis. The gene discussed is IL37; the disease is hepatitis A virus infection.