INPP5D and systemic lupus erythematosus: Taken together, by coculture hucMSCs-Exo with B cells of SLE patients, B-cells apoptosis can be promoted, B-cells proliferation can be inhibited, overactivation of B-cells can be prevented, inflammation can be alleviated, and disease progression can be slowed by reducing miR-155-targeting SHIP-1 in B-cells (Figure 7).