Autosomal dominant conditions such as Marfan syndrome (MFS) caused by variants in FBN1 gene (52), vascular Ehlers-Danlos syndrome (vEDS) caused by variants in COL3A1 (53) and Loeys-Dietz syndrome (LDS) caused by variants in TGFBR1, TGFBR2 and SMAD3 (54, 55), among other genes, have been considered as potential disorders favoring SCeAD (3, 56). Here, SMAD3 is linked to Loeys-Dietz syndrome.