AKT1 and laryngotracheoesophageal cleft: Zhang et al. (2019) verified that LAMB3 mediates apoptosis, proliferation, invasion, and metastasis of pancreatic cancers through the regulation of the PI3K/Akt signaling pathway. As a key gene involved in the progression of lung cancer, it showed high expression in LC tissues compared with normal ones (Wang et al., 2013).