Zhang et al. (2018) reported TINAG was highly expressed in hepatocellular carcinoma, which was related to three factors: pathological metastasis, pathological stage, and pathological node. It has also been confirmed that PI3K/AKT activation plays a major role in promoting TINAG-mediated migration, proliferation, and invasion. TINAG is a key gene related to the prognosis of pancreatic cancer (Liu et al., 2019). Here, AKT1 is linked to familial pancreatic carcinoma.