Zhang et al. (2019) verified that LAMB3 mediates apoptosis, proliferation, invasion, and metastasis of pancreatic cancers through the regulation of the PI3K/Akt signaling pathway. As a key gene involved in the progression of lung cancer, it showed high expression in LC tissues compared with normal ones (Wang et al., 2013). Here, LAMB3 is linked to familial pancreatic carcinoma.