ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: A reciprocal chromosome translocation (Zhao et al., 2014; Miceli and Kauffman, 2015), called the Philadelphia chromosome, leads to a constitutive activation of the BCR-ABL tyrosine kinase, resulting in CML (Nowell and Hungerford, 1960; Rowley, 1973; Goldman and Melo, 2003; Druker, 2008).