PLCG1 and infection: Among these, phospholipase C gamma 1 (PLCG1), a membrane-associated enzyme involved in cell growth and differentiation mediated by leucine kinase receptor signaling pathway, has been shown to induce pyroptosis by increasing the activity of GSDMD via intracellular calcium signaling, which is implicated in fatal infection (Kang et al., 2018; Liu et al., 2020).