Among the 8 patients with drug change, 2 patients (25.0%) chose to change due to abnormal liver function, 2 patients (25.0%) due to renal insufficiency, and 1 patient (12.5%) due to liver and kidney insufficiency, 2 patients (25.0%) due to pleural effusion, and 1 patient (12.5%) due to drug resistance and mutation in the ABL kinase region. The gene discussed is ABL1; the disease is Pleural effusion.