A similar approach was used to identify the causal gene in other UAE families, such as METTL23 in a large inbred UAE family of Yemeni origin with intellectual disability (Reiff et al., 2014) and SRD5A3 in another UAE family of Baluchi origin with a new type of glycosylation disorder (Cantagrel et al., 2010). Here, METTL23 is linked to Intellectual disability.