Due to the significant neuromodulatory, protective and nutritional effects of insulin on the brain, insulin resistance in the brain might exacerbate Aβ deposition, tau hyperphosphorylation, and vascular inflammation, causing cognitive impairments in AD and VaD (Hotamisligil, 2006; Kellar and Craft, 2020). The gene discussed is MAPT; the disease is Alzheimer disease.