In addition to the classical targets related to Aβ and tau protein hyperphosphorylation, lysosomal pathways, autophagy, apoptosis, transcription factor EB (TFEB), and TREM2 are also potential therapeutic pathways and targets for Alzheimer’s disease (AD) (Singh et al., 2019a; Rai et al., 2021). Here, TFEB is linked to early-onset autosomal dominant Alzheimer disease.