AKT1 and Alzheimer disease: Activation of PI3K/AKT signaling protects neurons from Aβ-induced neurotoxicity (Do et al., 2014), inhibits the formation of pathogenic neurogenic fiber tangles (NFT) (Kitagishi et al., 2014), and regulates synaptic plasticity (Spinelli et al., 2019), playing an important regulatory role in AD.