CASP3 and Alzheimer disease: EGFR is a potential therapeutic target for AD (Tsuji et al., 2021; Zhang et al., 2022).The protein encoded by CASP3 gene is a cysteine-aspartic acid protease that plays an important role in the execution-phase of cell apoptosis in AD, and the PI3K/AKT signaling pathway is the most important intracellular factor involved in regulation of cellular apoptosis (Khezri et al., 2023).