In addition to the classical targets related to Aβ and tau protein hyperphosphorylation, lysosomal pathways, autophagy, apoptosis, transcription factor EB (TFEB), and TREM2 are also potential therapeutic pathways and targets for Alzheimer’s disease (AD) (Singh et al., 2019a; Rai et al., 2021). The gene discussed is MAPT; the disease is Alzheimer disease.