Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype can further be divided into 3 subtypes: diffuse pediatric-type high-grade glioma RTK2, diffuse pediatric-type high-grade glioma RTK1, and diffuse pediatric-type high-grade glioma MYCN (Korshunov et al., 2017; Ellison et al., 2019). This evidence concerns the gene IDH1 and central nervous system cancer.