For instance, IDH-wildtype diffuse astrocytoma or anaplastic astrocytoma with EGFR amplification, combined whole chromosome 7 gain and whole chromosome 10 loss (+7/−10) or TERT promoter mutation, resembles IDH-wildtype glioblastoma in the aggressive clinical course, underlining the importance of combining histopathology and molecular pathology in diffuse glioma diagnosis (Brat et al., 2018). This evidence concerns the gene IDH1 and anaplastic astrocytoma.