EGFR and anaplastic astrocytoma: For instance, IDH-wildtype diffuse astrocytoma or anaplastic astrocytoma with EGFR amplification, combined whole chromosome 7 gain and whole chromosome 10 loss (+7/−10) or TERT promoter mutation, resembles IDH-wildtype glioblastoma in the aggressive clinical course, underlining the importance of combining histopathology and molecular pathology in diffuse glioma diagnosis (Brat et al., 2018).