Adult cases of diffuse astrocytoma or anaplastic astrocytoma, IDH-wildtype failing to fall into glioblastoma, IDH-wildtype for lack of EGFR amplification, +7/−10 and TERT promoter mutation, should undergo additional molecular tests (e.g., MYB, MYBL1, BRAF, FGFR1, histone H3) and may be classified as certain subtype of pediatric-type diffuse glioma (Gritsch et al., 2022). The gene discussed is MYBL1; the disease is diffuse astrocytoma.