HCRT and epilepsy: In addition, exogenous extra orexin A/B was found to increase penicillin-induced epileptic activity (Kortunay et al., 2012), and orexin receptor antagonisms were observed to reduce seizures in multiple epilepsy models (Zhu et al., 2015; Roundtree et al., 2016; Kordi Jaz et al., 2017).