AGT and hypertensive disorder: Leng et al. (2015) focused on the neuroprotective role of FGF21, indicated that FGF21 can protect primary neurons from glutamate-induced excitotoxicity. Moreover, FGF21 reduces neuroinflammation and oxidative stress through regulating two pathways (Kang et al., 2020). In addition, FGF21 is related to hypertension, an important risk factor for ICH (Semba et al., 2013). FGF21 plays an important role in preventing angiotensin II-induced hypertension and vascular dysfunction (Pan et al., 2018).