In this study, we determined the influence of the NLRP1 level on the degree of coronary stenosis and prognosis of patients with coronary artery disease by detecting the level of NLRP1 in the serum of patients with coronary artery disease, in order to explore new targets and new strategies for the prevention and treatment of coronary atherosclerotic artery disease. The gene discussed is NLRP1; the disease is coronary artery disorder.