NLRP3 and obesity due to melanocortin 4 receptor deficiency: Moreover, obesity activates inflammasomes such as NOD-like receptor family pyrin domain-containing 3 (NLRP3), which is involved in diseases such as non-alcoholic fatty liver disease (NAFLD) (Yu et al., 2022), Type 2 diabetes (Gora et al., 2021), and chronic kidney disease (CKD) (Ke et al., 2018)).