Several experiments indicate that PrPc is involved in physiological processes, including neurogenesis, neuroprotection, copper homeostasis, synaptic plasticity, myelin sheath maintenance, and cellular signaling pathways (Mitteregger et al., 2007; Bremer et al., 2010; Altmeppen et al., 2012) and also in pathological mechanisms of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases (Brody and Strittmatter, 2018; Nieznanska et al., 2021; Shafiq et al., 2022). This evidence concerns the gene PRNP and neurodegenerative disease.