identified deglycase DJ-1 (encoded by the PARK7 gene, a critical familial Parkinson’s disease gene) as a pacemaker regulating pyruvate dehydrogenase (PDH) activity in CD4 regulatory T cells; Deglycase DJ-1 binds to PDHB in Tregs and inhibits the phosphorylation of PDHA, thereby promoting PDH activity and oxidative phosphorylation to keep T cells functional integrity and the differentiation of Treg cells (64). This evidence concerns the gene PDP1 and Parkinson disease.