From there, the inflammatory response during periodontitis has been shown to be marked by the local release of specific proinflammatory mediators and enzymes, including C-reactive protein (CRP); metalloproteinases (MMPs); interleukin- (IL-) 1β, IL-6, and IL-10; and tumor necrosis factor (TNF-α). The gene discussed is TNF; the disease is periodontitis.