Interestingly, OCB appears to be relatively more prevalent in ALS cases with distinct genetic causes [3/12 in genetic ALS cases vs. 6/247 in sporadic; the three cases presenting TDP-43 or ANG-2 mutations; (28)] and with distinctive presentation and clinical course (cerebellar involvement and hyperintense lesion in white matter). Here, TARDBP is linked to amyotrophic lateral sclerosis.