Previous studies reported a significant amelioration of the cognitive impairment in different AD mouse models upon the reduction in p75NTR expression level by knocking it out (Murphy et al., 2015; Jian et al., 2016; Qian et al., 2018) or by application of small molecule ligands modulating p75NTR function (Nguyen et al., 2014; Simmons et al., 2014). This evidence concerns the gene NGFR and Alzheimer disease.