APP and Alzheimer disease: The analysis revealed a strong activation of MDMs in AD mice compared to WT (one-way ANOVA: F(3,12) = 22.29, p < 0.0001; WT: 6.218 ± 0.748; p75NTR KO: 5.393 ± 0.569; APP/PS1tg: 30.59 ± 4.167; APP/PS1tg x p75NTR KO: 32.83 ± 4.696; WT vs. APP/PS1tg: p < 0.001, WT vs. APP/PS1tg x p75NTR KO: p < 0.001, p75NTR KO vs. APP/PS1tg x p75NTR KO: p > 0.001).