On the other hand, the analysis performed upon its deletion in vivo in different mouse models of AD (Wang et al., 2011; Murphy et al., 2015; Jian et al., 2016; Qian et al., 2018) did not unequivocally confirm the role of p75NTR in the pathogenesis and progression of the disease. The gene discussed is NGFR; the disease is Alzheimer disease.