SOX2 and non-small cell lung carcinoma: Our experimental results showed that upregulation of SOX2 expression enhanced the migration ability of NSCLC cells and silencing of SOX2 caused diminished cell migration ability, which combined with changes in cellular resistance to radiotherapy, suggested that SOX2 might affect radiotherapy sensitivity by regulating cell migration movement, but the specific regulatory pathway of SOX2 on migration invasion of NSCLC cells needs to be investigated in depth.