In our study, the same association was found between SOX2 and CSC phenotype: upregulation of SOX2 caused elevated expression of NSCLC CSC markers CD133 and ALDH and enhanced cell sphericity, while downregulation of SOX2 decreased cellular CD133 expression and sphericity, and changes in cell stemness characteristics corresponded to altered sensitivity to radiotherapy. The gene discussed is LDHA; the disease is non-small cell lung carcinoma.