Zhao et al. investigated whether lansoprazole, alone or in combination with gefitinib, induced apoptosis and G0/G1 cell cycle arrest in non-small-cell lung cancer A549 cells by inhibiting Stat3 phosphorylation, PI3K/Akt signaling, and Raf/ERK signaling 24. This evidence concerns the gene STAT3 and non-small cell lung carcinoma.