Moreover, increased D2-40+ LVD was positively associated with CD8+PD1+ TILs or CD8+LAG3+ TILs, indicating the increased CD8+ T cells in ccRCC patients with lymphangiogenesis may exhibited an exhausted phenotype due to the upregulation of these immunosuppressive molecules. This evidence concerns the gene PDPN and nonpapillary renal cell carcinoma.