AKT1 and hereditary clear cell renal cell carcinoma: Analysis of the KEGG pathway revealed that differentially expressed LRGs were significantly correlated with cancer-related pathways, including the PI3K-Akt signaling pathway, MAPK signaling pathway, Ras signaling pathway, focal adhesion, JAK-STAT signaling pathway, renal cell carcinoma, and VEGF signaling pathway (Figure 2D).