In ccRCC patients, the top 20 genes with the highest mutation rates were: VHL, PBRM1, TTN, SETD2, BAP1, MUC16, MTOR, KDM5C, HMCN1, LRP2, DNAH9, ATM, CSMD3, ARID1A, KMT2C, DST, USH2A, SMARCA4, ERBB4, AHNAK2 (Figure 10A). This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.